Matchmaker Exchange welcomes the chance to work with you.

To get started matching a case, see the instructions below.

  • Individual case queries or full datasets may be submitted via any of the portals currently connected to MME. To search the MME for matches, each data querier must adhere to the MME End User Agreement.
  • Entry of a case into a MME database may require consent depending on the content entered. For guidance, click here.
  • To begin querying, choose one of our participating services to deposit your case. Use the charts below to compare the location of the database, the types of data stored by each MME service and the parameters used by each for matching and score output. You may click on each database to be directed to their website for additional guidance and to begin querying.
  • If you have a dataset you'd like to deposit into one of the participating matchmaker services to make available for matching, you may also use the instructions below as a guide. We recommend contacting the database to ask for any special instructions on depositing a dataset.

Matchmaker Services Connected by the MME API:

Types of Data Stored by Each of the Participating Matchmaker Exchange Services

Service Phenotype   Genotype Candidates
Condition Name Diagnosis Code Phenotypic Terms Non-Human Models Gene ID Chromosomal Coordinates Flagged Candidate Variants VCF Files or Equivalent Flagged Gene Candidates Evidence for Gene Candidates Variant Classification Variant Evidence
AGHA Patient Archive (Australia)          
DECIPHER (UK)          
GeneMatcher (USA)        
matchbox (USA)              
Monarch Initiative (USA)              
MyGene2 (USA)        
PhenomeCentral (Canada)  

Parameters Used for Matching and Score Output

Service Gene ID Diagnosis Code Phenotypic Terms Variant Parameters Provides Match Score Output
AGHA Patient Archive (Australia) Coming soon  
DECIPHER (UK)  
GeneMatcher (USA)
matchbox (USA)    
Monarch Initiative (USA)      
MyGene2 (USA) Coming soon Coming soon  
PhenomeCentral (Canada)  

Matchmaker Exchange Connections

Responding Service
Querying Service AGHA Patient Archive DECIPHER GeneMatcher matchbox Monarch Initiative MyGene2 PhenomeCentral
AGHA Patient Archive (Australia)   Coming Soon Coming Soon
DECIPHER (UK) Coming Soon   Coming Soon   Coming Soon
GeneMatcher (USA)    
matchbox (USA)   Coming Soon      
Monarch Initiative (USA)              
MyGene2 (USA) Coming Soon Coming Soon    
PhenomeCentral (Canada)  

Types of Users

Service Clinicians Patients Researchers
AGHA Patient Archive (Australia)  
DECIPHER (UK)  
GeneMatcher (USA)
matchbox (USA)  
Monarch Initiative (USA)  
MyGene2 (USA)
PhenomeCentral (Canada)  

 

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